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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Exceptionally rare IDH1-mutant adult medulloblastoma with concurrent GNAS mutation revealed by in vivo magnetic resonance spectroscopy and deep sequencing

Fig. 3

Adjacent sections from a representative tumor area show unexpectedly large areas of strong GFAP immunoreactivity (A and inset; asterisk indicate GFAP-enriched areas) along with areas of classical robust Synaptophysin expression (B and inset; asterisk indicate Synaptophysin-enriched areas). Double immunostain combining GFAP and Synaptophysin indicates that expression of GFAP (brown, cytoplasmic positivity) and Synaptophysin (blue, cytoplasmic positivity) are mostly mutually exclusive (C and inset). Interestingly, double immunostain for GFAP (brown, cytoplasmic positivity) and EBF3 (blue; nuclear positivity), a recognized marker of early neuronal differentiation in medulloblastoma, shows selective EBF3 expression in the GFAP-negative tumor cells (D and inset)

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