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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease

Fig. 8

Morphological abnormalities in flat-mounted retinas of APP/PS1 mice. a Upper panel showing retinal area at low magnification, botom panels showing at higher magnification representative images of melanopsin immunoreactivity in the retina of wt and APP/PS1 mice (scale bar 50 µm). b The results of total analysis of retina showing reduced mRGC number in APP/PS1 mice compared to wt mice (n = 3–6 mice per group). c At high magnification (lower panels), melanopsin staining revealed abnormal morphology in the dendritic processes of mRGC with smaller boutons en passant in APP/PS1 mice (scale bar 10 µm). d Size analysis of these boutons en passant showed a significant reduced size in both 6- and 12-month-old APP/Ps1 mice compared to age-matched wt group. Note lower size of boutons en passant with age (n = 4 mice per group). Data are expressed as mean ± SD. **p < 0.01; ***p < 0.001; ****p < 0.0001 using two way ANOVA followed by Bonferroni’s multiple comparison post-test. mRGCs melanopsin retinal ganglion cells, wt wild type

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