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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease

Fig. 1

Altered expression profile of clock genes in the hypothalamus of APP/PS1 mice. a Schematic table symbolizing the circadian rhythmicity of clock genes, indicating diurnal (light) or nocturnal (dark) acrophase, in the studied mice groups. bh Transcript levels from wt (filled circles) and APP/PS1 mice (filled squares) 6- and 12-month-old mice at ZT 1, 7, 13, and 19 for b Clock, c Arntl, d Cry1, e Cry2, f Per1, g Per2, and h Per3. Dashed lines indicate the time of acrophase for each mice group. 4–5 mice per time point and group were analyzed. Mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 using two-way ANOVA and Bonferroni’s multiple comparison post-test. wt wild type, ZT Zeitgeber Time

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