Fig. 2

Modulation of the HGF/MET pathway by irradiation in vitro. A,B. The cells were untreated or exposed to irradiation in the absence or presence of tepotinib as pre (8 h)- and co-treatment (100 nM), and 24 h later assessed for expression of Hgf and Met mRNA (A) or for MET and p-MET levels by immunoblot (B). C. Cells were exposed to irradiation in the absence or presence of tepotinib at 100 nM or HGF at 50 ng/ml or both and were then monitored for clonogenic survival (n = 6, mean and SEM; * p < 0.05, **p < 0.01, *** p < 0.001 relative to control)