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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas

Fig. 2

CircRNAs validated by qRT-PCR and RNA-FISH in cell lines, PDXs, and clinical MB patient samples. A and B Fold change for normal cerebellum (CB) in medulloblastoma cell line samples (A) and PDX samples (B). Values indicate fold change relative to cerebellum. *p < 0.05, **p < 0.01, Kruskal–Wallis analysis. C and D RNA-FISH confirms that circ_63706 expression is specific to SHH medulloblastoma patients. C Representative RNA-FISH analysis of circ_63706 in medulloblastoma tissues. RNA-FISH analysis of circ_63706 in SHH medulloblastoma patients (top panels) and G3 and G4 medulloblastoma patients (lower panels). D Spot numbers relate to circ_63706 per cell in SHH, G3, and G4 medulloblastoma patients. n = 20, *p < 0.01, Student’s t-test. E Kaplan–Meier survival curves of SHH medulloblastoma patients according to circ_63706 expression. SHH medulloblastoma patient samples were divided into circ_63706 high (average spot number per cell > 1.0) and circ_63706 low (average spot number per cell < 1.0)

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