Fig. 6

DNA methylation and chromosomal copy number alterations occur at specific markers over time. A Proportion of astrocytomas and oligodendrogliomas over time based on CDKN2A/B status (left) and MGMT promotor methylation status (right). B CDKN2A/B status and MGMT promotor methylation status were stable throughout tumor progression of oligodendrogliomas whereas these markers were commonly altered over time in astrocytomas. 1p/19q-codeleted (blue) or retained (light blue). CDKN2A/B homozygous deleted (red) or retained (pink). Methylated MGMT promotor (green), unmethylated MGMT promotor (light green) and MGMT homozygous deleted (black). Tumor cases with indication of hyperdiploidy are represented in the figure with an asterisk (*)