Fig. 5

DNA methylation changes at specific CpG sites occur during tumor progression. A The number of differentially methylated positions (DMPs) between the primary tumor and first recurrence of individual patient varies between patients, and B only few DMPs were shared between most of the patients. C Astrocytomas accumulated significantly more DMPs over time compared to oligodendrogliomas. D The number of DMPs tended to increase with increasing CNS WHO tumor grade, E but DMPs were not associated with the time between the primary tumor and first recurrence. *Denotes significance (p-value < 0.05). The tumor samples are color-coded by patient identity, and this applies to A and E panels