Fig. 3
From: Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
Transcriptomic analysis of inherited and sporadic late-onset nemaline myopathies (A) Bulk RNA sequencing was performed from sporadic late onset nemaline myopathy (SLONM) and inherited nemaline myopathy (iNM) muscle samples. (B) Transcriptomic analysis demonstrated 32 differentially expressed genes between the two disorders. (C) A heat map demonstrates the differential transcriptomic profiles of iNM and SLONM patient samples. (D) Principal component analysis showed differential clustering of iNM and SLONM transcriptomic profiles. (E) Ingenuity Pathway Analysis identified several pathways differentially expressed between the two disorders, the top 10 of which are illustrated here. (F) Differentially expressed genes in these pathways included several sarcomeric proteins, some of which were represented in multiple pathways. Bars represent mean ± SEM