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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies

Fig. 1

Quantitative myopathological analysis of inherited and sporadic late-onset nemaline myopathies (A) Unbiased quantitative myopathological analysis was performed by systematic random sampling of digitized images of muscle sections. The distribution of nemaline rods in muscle fibers was categorized as (B) subsarcolemmal aggregates, (C) central aggregates, or (D) diffuse. (E) In some inherited nemaline myopathy samples, > 90% of fibers contained rods. (F) Atrophic fibers filled with rods, (G) necrotic fibers (*), and increased endomysial connective tissue (arrow) were seen almost exclusively in sporadic late-onset nemaline myopathy. (H) In inherited nemaline myopathy (iNM), fibers containing nemaline rods were more frequent than in sporadic late onset nemaline myopathy (SLONM). Bars represent mean ± standard deviation. (I) The diameters of fibers containing rods were  larger in iNM than in SLONM. Lines represent the mean of each group. (J) In iNM, rods were most often found in aggregates, whereas they were diffusely distributed in SLONM. (K) Necrotic fibers, regenerating fibers, atrophic fibers filled with rods, and increased endomysial connective tissue were all more common in SLONM. A–F: modified Gomori trichrome stain, G: hematoxylin and eosin, scale bar = 20 µm in all panels, *p < 0.05

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