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Table 1 T2WI and DTI reveal tissue-level alterations 12 m following jmTBI (t-values)

From: A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age

Region

Ipsilateral

Contralateral

T2

FA

MD

AD

RD

T2

FA

MD

AD

RD

Hippocampus

 CA1

1.10

0.19

0.37

1.15

0.37

0.49

0.94

0.31

0.06

0.99

 CA2

1.62

1.42

2.26#

2.05

2.30#

2.93*

1.72

0.27

0.47

0.18

 CA3

1.64

0.44

1.36

1.01

1.24

0.10

0.35

0.14

0.36

0.02

 DG

0.85

1.99

0.86

0.26

1.07

0.19

0.78

1.33

0.29

1.53

Basal forebrain

 SI

0.12

5.04*

1.92

1.69

1.34

0.70

0.34

0.49

0.76

0.23

 NB

0.81

1.89

0.41

0.14

2.93*

0.75

1.52

2.60*

2.43#

2.54*

 MS

0.72

0.6

0.76

0.17

0.38

0.40

0.63

0.11

0.10

0.10

  1. Sham vs. jmTBI. T2 (ms), MD (mm2/s), AD (mm2/s), RD (mm2/s)
  2. DG Dentate gyrus; SI Substantia innominate (ventral palladium); NB Nucleus basalis; MS Medial septal nucleus. *P < 0.05, #P < 0.1 (indicated in bold)