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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: A single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age

Fig. 9

Impaired learning was found 12 m after jmTBI. A Illustration of the platform positions (blue) and two release positions for the animals (a, b arrows) within the Morris water maze (MWM, top panel). Spatial learning during the MWM was impaired in the jmTBI cohort, with increased cumulative distance to the platform over the trials during the learning task. B In the probe test for spatial memory, the jmTBI mice had no significant preference for the platform (P) quadrant (in green) (left panel), whilst sham animals spent significantly more time in the platform quadrant compared to the other quadrants (right panel). The release point of the mice is indicated with R. Two-way ANOVA with Sidak post-hoc test. Data expressed as mean + SEM. *P < 0.05, **P < 0.01, ***P < 0.001 (Created with BioRender.com)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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