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Table 4 Summary of passage 2 results

From: Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice

Inocula

Clinical

DPI

IHC

RT-QuIC

Blot

MV1-BH (ms)

8/8

166 ± 3

6/6

3/3

4/4

MV1-OH (ms)

8/8

166 ± 5

6/6

3/3

6/6

MV2-BH (ms)

12/12

413 ± 11

6/6

3/3

6/6

MV2-OH (ms)

12/12

392 ± 10

6/6

3/3

6/6

Uninfected

0/4

177 ± 0

0/4

0/4

0/5

  1. Clinical: mice showing terminal prion disease. DPI days post inoculation to euthanasia, IHC immunohistochemistry for PrP deposition; RT-QuIC: results of Real-Time Quaking Induced Conversion assay; Blot: results of western blotting for PrPRes; x/y indicate total positive out of total tested
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Acta Neuropathologica Communications

ISSN: 2051-5960

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