Inocula | Clinical | DPI | IHC | RT-QuIC | Blot |
|---|
MV1-BH | 10/10 | 176 ± 4 | 4/4 | 3/3 | 3/3 |
MV1-OH (B) | 0/9 | NA | 0/7 | 1/9 | 1/1 |
MV1-OH (E) | 0/5 | NA | 1/6 | 2/7 | 2/2 |
MV2-BH | 10/10 | 420 ± 23 | 4/4 | 3/3 | 3/3 |
MV2-OH (B) | 8/8 | 501 ± 85 | 8/8 | 8/8 | 1/1 |
MV2-OH (D) | 7/9 | 536 ± 56 | 8/8 | 9/9 | 3/3 |
NBH-OH (A) | 0/8 | NA | 0/8 | 0/8 | 0/3 |
- Clinical: mice showing terminal prion disease. Mice found dead or euthanized for non-TSE related reasons were not counted towards the total, although tissue may have been used for other assays; DPI days post inoculation to euthanasia, IHC immunohistochemistry for PrP deposition, RT-QuIC results of real-time quaking induced conversion assay; Blot: results of western blotting for PrPRes; x/y indicate total positive out of total tested. Letters in parenthesis are identifiers to link the inoculating organoids to the original study [10]
