Fig. 4

Second pass mice show PrP deposition consistent with original inoculum subtype. Immunohistochemistry of second pass mice shows maintained differences in PrP deposition patterns between prion subtypes and similarities between MV-BH (ms) and MV-OH (ms) inoculated mice. Small boxes in the cross section correspond to the expanded images on the right. Brain regions are indicated across the top and inocula are listed on the left of the image. Scale bars indicate 1 mm and 50 µm for whole brain and insets, respectively