Fig. 2

OH inoculated mice show PrP deposition consistent with the original BH subtype inoculated mice. Immunohistochemistry for prion protein (brown staining) showing distinct differences in deposition patterns between prion subtypes but similarities between mice inoculated with brain or organoid homogenate. Brain regions are indicated across the top and inocula are listed on the left of the image. Small boxes in the cross section correspond to the expanded images on the right. Scale bars indicate 1 mm and 50 µm for whole brain and insets, respectively