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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration

Fig. 4

A Specific enzymatic activity of the three lysosomal enzymes cathepsin D (CTSD), cathepsin L (CTSL), and β-Glucocerebrosidase (GCase) in brain lysates of 6-month-old wildtype, Grn−/−, Grn−/− × Tmem106bT186S/T186S mice (n = 4, each genotype) (upper panel) and 10-month-old mice (lower panel). B The levels of the BMP species with different fatty acid compositions (di18:1, di22:6, and 20:4/22:6) were quantified in lipid extracts of the brain from 6-month-old wildtype, Grn−/−, Grn−/− × Tmem106bT186S/T186S mice (n = 8, each genotype) by mass spectrometry

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