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Table 1 Cell types identified via scRNA-seq

From: PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth

Cluster #

Designation

Atoh1-lineage?

Population difference

p value

KO versus control

0

Proliferating CGNPs

Yes

Up in control

1.00E−14

1

Differentiating CGNs

Yes

Up in control

8.40E−14

2

Early differentiating CGNPs

Yes

up in control

1.00E−14

3

Late mitotic CGNPs

Yes

Up in control

1.00E−14

4_0

Interneurons

No

  

4_1

Hox + CGNPs

Yes

Up in EedcKO

1.84E−05

5

Proliferating CGNPs

Yes

Up in EedcKO

1.03E−07

6_0

Early interneuron progenitors

No

  

6_1

Cdkn2a + proliferating CGNPs

Yes

Up in EedcKO

3.34E−07

7

Astrocytes

No

Up in control

0.000213

8

Hox + differentiating CGNs

Yes

Up in EedcKO

2.91E−10

9

Oligodendrocytes

No

  

10

Mitotic CGNPs

Yes

Up in control

5.67E−10

11

Vascular fibroblasts

No

Up in control

0.0351

12

Myeloid

No

  

13

Endothelial cells

No

  

14

CGNs

Yes

  

15

Myocytic cells

Yes

Up in EedcKO

0.000945

16

Early differentiating CGNPs

Yes

Up in control

0.00127

17

Purkinje cells

No

Up in control

0.0214

18

Pericytes

No

Up in EedcKO

0.00831

19

Ependymal cells

No

  
  1. Cluster numbers and corresponding cell types, with Atoh1-lineage cells identified, CGNP and CGN clusters are in bold, and population differences noted between EedcKO and WT, with p values determined by Dirichlet regression analysis