Fig. 6
Up-regulation of PRC2 targets and myoid differentiation in both Eed-deleted and Ezh2-deleted SHH medulloblastomas. A Representative CDKN2A IHC in medulloblastomas of indicated genotypes, with quantification in replicate mice of each genotype. B Representative images of CDKN2A/pRB dual staining and quantification of pRB + fractions of CDKN2A-expressing cells in the indicated ages and genotypes. C Representative MYOG and SMYD1 IHC in medulloblastomas of indicated genotypes with quantification of MYOG + cells in replicate mice of each genotype. D Representative H&E-stained section from a medulloblastoma in a M-Smo/Ezh2cKO mouse, with myoid cells (arrows), and quantification in replicate mice of the indicated genotypes. *, **, and *** denote p < 0.05, p < 0.01 and p < 0.001 respectively, relative to controls