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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth

Fig. 3

Expression of PRC2 targets in EedcKO and Ezh2cKO cerebella. A Bubble Plot shows the magnitude and frequency of the expression of indicated genes in each cluster, and feature plot of Cdkn1a + cells (red), color-coded over the UMAP from (2C). B Feature plots of Hoxa9+, Hoxa7+, and Cdkn2a+ cells (red), color-coded over the UMAP from (2C). C and D Representative immunofluorescence in sagittal sections of WT, EedcKO, and Ezh2cKO cerebella, showing expression of C CDKN2A or D MYOG and SMYD1, with DAPI counterstain. The CDKN2A + and MYOG + fractions in cerebellar sections from 3 replicate mice of indicated genotypes are graphed on the right. EedcKO, and Ezh2cKO replicates were compared to controls using one-tailed Student’s t-tests and to each other using two-tailed Student’s t-tests. *, **, and *** denote p < 0.05, p < 0.01 and p < 0.001 respectively

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