Fig. 6
From: CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
SLC7A11/xCT expression and its protein levels are significantly reduced in CIC OE TS603. A Differential gene expression analysis of RNA-seq in TS603 Ctrl and CIC cells. B SLC7A11 mRNA expression in TS603 Ctrl and CIC cells as validated by RT-qPCR. C Glutamate levels (lower) in TS603 ectopically expressing Ctrl or xCT (upper). D SLC7A11/xCT protein levels in TS603 Ctrl and CIC cells transduced with xCT. (E) SLC7A11 mRNA expression in the indicated NHA derivatives from GSE103514 dataset. Mean ± SEM of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001