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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: CIC reduces xCT/SLC7A11 expression and glutamate release in glioma

Fig. 3

Effect of phosphorylation-insensitive form of CIC on its repressor activity and cell proliferation. A CIC interaction partners identified by mass-spectrometry of Flag immunoprecipitated TS603 cells ectopically expressing Flag-CIC or Flag-CIC (S173A). The indicated proteins with tT-test difference > 1 are highlighted in red (CIC-specific), green (S173A-specific), and blue (CICS173A-specific). B ETV protein levels in TS603 cells transduced with Ctrl, CIC-S or CIC-S (S173A). C The mRNA expression of CIC targets in TS603 cells expressing Ctrl, CIC-S or CIC-S (S173A). D Cell proliferation rate of TS603 cells expressing Ctrl or CIC-S (S173A). E The expression of CIC target genes in R18 (14-3-3 inhibitor)-treated TS603 cells as determined by qPCR. The expression was normalized to values from untreated cells as a control. Mean ± SEM of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001

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