Fig. 1
From: CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Identification of CIC alterations in IDHmut-codel gliomas. A CIC mutation rate stratified by each patient’s glioma subtype and tumor progression. B CIC mutation type in the initial and recurrent IDHmut-codel gliomas. C CIC expression in adult glioma subtypes (IDHmut codel CICmut, n = 47; IDHmut codel CICwt, n = 38; IDHmut non-codel, n = 141; IDHwt, n = 55). ***p < 0.001. D CIC mutation status in IDHmut-codel tumorspheres. E CIC and ETV4 protein levels in glioma tumorspheres and human neural progenitor cells (NPCs). F Doublings per day of IDHmut-codel tumorspheres. Mean ± SEM of at least three independent experiments. **p < 0.01, ***p < 0.001