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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking

Fig. 5

POPDC mutations have varying impacts on POPDC1 and POPDC2 sarcolemmal expression in skeletal muscle. Comparison of the fold change in POPDC1 and POPDC2 expression, normalized to SGCA, in the sarcolemma of skeletal muscle fibers from biopsy material of patients carrying the POPDC1 p.V183F and POPDC1 p.Q153X variants and a homozygous Popdc2 p.W188X knock-in mouse compared to matched controls or wild-type mouse. The total number of fibers analyzed are shown at the base of each bar. Data is displayed as median ± 95% CI. POPDC1 and POPDC2 values were compared using Kruskal–Wallis followed by Dunn’s multiple comparisons test; * p < 0.05; ** p < 0.01; **** p < 0.0001

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