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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice

Fig. 6

Polycomb repressor complex 1 (PRC1) proteins are upregulated in cerebellar vGluT2+ neurons. A Overrepresentation analysis against ChEA ChIPseq gene sets from mouse embryonic stem cells (ESCs/MESCs) show DEGs detected in vGluT2+ neurons are overrepresented among targets associated with polycomb repressor complex (PRC) proteins (FDR ≤ 0.01). B PRC-associated DEGs show similar distribution between up and down-regulated DEGs. C PRC1 protein genes Cbx2, Cbx4, Cbx8 and Pcgf2 are significantly upregulated in cerebellar vGluT2+ neurons (green) in HD, whereas PRC2 core protein genes (Eed, Ezh1, Ezh2, Suz12) and associated factors (Aebp2, Jarid2, Rbbp4) are not differentially expressed. (* FDR ≤ 0.05; ** FDR ≤ 0.01; *** FDR ≤ 0.001)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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