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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice

Fig. 2

S4-HdhQ200 mice show HD-typical neuropathology by 9 months of age. A Htt aggregates (2 examples marked with arrowheads) present in 9 months (mos) old HD striatum (A), were absent from 9 mos old control striatum (B). C Overview of brain regions analyzed. DF The proportion of aggregates per cell (D), the percent of aggregates that are NIIs (E), and the number of RNA molecules detected per cell (F). All charts share the key in (F), using the same color scheme as in (C); statistical analyses are presented in Fig. S2. GH Representative images of RNA ISH for Ppp1r1b in 9 mos old brain sections (G), and quantification and analysis in (H). Unpaired t-test without corrections for multiple testing (***p < 0.001). The scale bar in (B) represents 25 µm, and the scale bars in (G) represent 100 µm

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