Fig. 4
From: Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology
Quantified immunoblots of three proteins related to the cadherin-catenin complex. Immunoblotting was performed using whole hippocampal tissue of 15 SD patients and 15 non-demented controls. β-catenin/CTNNB1 was insignificantly increased in SD patients versus controls (FC 1.34, P-value 0.20). Immunoblotting of γ-catenin/JUP showed a similar trend (FC 1.29, P-value 0.34). For N-cadherin/CDH2, 14 SD samples were included in the analysis (as GAPDH immunoblot failed for one sample [#SD12]), revealing a significant difference between patients and controls (FC 1.59, P-value 0.01). Original images of one immunoblot gel are shown below the respective boxplots, with SD = semantic dementia patients, and C = controls. An overview of all immunoblots is provided in Additional file 1: Fig. S5, and all quantified data can be found in Additional file 2: Table S9