Table 1 Demographic and clinical characteristics of the study cohort
Total (n = 22) | Controls (n = 5) | Individuals with hypertension (n = 17) | p value | |
|---|---|---|---|---|
Demographics | ||||
Age, mean ± SD, years | 80.6 ± 8.1 | 80.2 ± 8.6 | 80.7 ± 8.2 | p = 0.905 |
Sex, female, n (%) | 10 (45.5%) | 3 (60.0%) | 7 (41.2%) | p = 0.457 |
Post-mortem delay, mean ± SD, hours | 22.4 ± 6.8 | 20.0 ± 2.9 | 23.1 ± 7.4 | p = 0.375 |
Risk factors | ||||
BMI, mean ± SD, kg/m2 | 23.1 ± 4.4 | 23.8 ± 3.8 | 22.9 ± 4.7 | p = 0.756a |
Diabetes, n (%) | 5 (22.7%) | 1 (20.0%) | 4 (23.5%) | p = 0.869 |
Hypercholesterolemia, n (%) | 11 (50.0%) | 1 (20.0%) | 10 (58.8%) | p = 0.127 |
Smoking, n (%) | 7 (31.8%) | 2 (40.0%) | 5 (29.4%) | p = 0.655 |
Alcohol use, n (%) | 3 (13.6%) | 0 (0%) | 3 (17.6%) | p = 0.312 |
WMH burden | ||||
Fazekas score, moderate to severe WMH (Score ≥ 2), n (%) | 10 (45.5%) | 0 (0%) | 10 (58.8%) | p = 0.020* |
WMH volume b, mean ± SD, mL | 1.40 ± 0.68 | 0.91 ± 0.26 | 1.54 ± 0.70 | p = 0.020* |
Fazekas score | ||||
0, n (%) | 3 (13.6%) | 1 (20.0%) | 2 (11.8%) | |
1, n (%) | 9 (40.9%) | 4 (80.0%) | 5 (29.4%) | |
2, n (%) | 9 (40.9%) | 0 (0%) | 9 (52.9%) | |
3, n (%) | 1 (4.6%) | 0 (0%) | 1 (5.9%) | |
Modified Fazekas score | ||||
Mild [0–1], n (%) | 12 (54.5%) | 5 (100%) | 7 (41.2%) | |
Moderate [2], n (%) | 9 (40.9%) | 0 (0%) | 9 (52.9%) | |
Severe [3], n (%) | 1 (4.6%) | 0 (0%) | 1 (5.9%) | |