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Fig. 10 | Acta Neuropathologica Communications

Fig. 10

From: Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor

Fig. 10

H2O2 signaling and Ctgf production are critical for efficient nerve repair. Schematic representation of the local H2O2 signaling triggered by acute peripheral nerve injury and its role in nerve recovery. Upper panels: acute damage to the sciatic nerve triggers a rapid, local production of H2O2 that, in turn, stimulates the YAP-dependent expression of Ctgf by SCs, promoting efficient and polarized nerve regeneration. Middle panels: H2O2 neutralization by catalase inhibits Ctgf expression, causing a misdirected migration of SCs and disorganised axonal re-growth. Lower panels: The same misdirected SC migration occurs upon antibody-mediated neutralization of Ctgf

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