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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy

Fig. 3

In vivo electrophysiological assessment of functional changes in the visual system in HE-P301S mice at 6 and 9 months of age. A Configuration for the recording of visually evoked potentials (VEP) with light stimulation of the eye and a cortical electrode. B Representative VEP recording showing the three typical N1, P1 and N2 waves in HE-P301S (red traces) and wild type (WT: blue traces) mice at the ages of 6 and 9 months. C Latencies of the N1 (top) and N2 (bottom) waves in 6-month-old and D 9-month-old WT- and HE-P301S mice at various light irradiance values (6 M for N1 waves: *p = 0.0418; *p = 0.0493; *p = 0.0340; for N2 waves: **p = 0.0063; *p = 0.0244; *p = 0.0116; unpaired Welch t test for comparison between HE-P301S and WT mice) (9 M for N1 waves: ns, p = 0.2370; ns, p = 0.2355; ns, p = 0.1244; for N2 waves: ns, p = 0.23434; ns, p = 0.0663; *p = 0.0147; unpaired Welch t test for comparison between HE-P301S and WT mice). E Latency of the N1 wave of 6-month-old mice at various stimulus frequencies (**p = 0.0047; *p = 0.0491; unpaired Welch t test). F Photopic ERG recordings in WT- and HE-P301S mice aged 6 and 9 months. Quantification of latencies (G) and amplitudes (H) for photopic ERG recordings for WT and HE-P301S mice at 6 and 9 months, respectively (p = 0.03; unpaired Welch t test) in photopic conditions at a light intensity of 20 cds/m2

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