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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Parkin coregulates glutathione metabolism in adult mammalian brain

Fig. 6

Working model for parkin-dependent effects on the cytosolic redox state in mammalian brain. Graphical depiction of redox changes identified herein, and as published. Highlighted are: GSH recycling; generation of ROS levels (i.e., H2O2; superoxide) leading to parkin’s variable states of oxidation [53]; protein carbonylation [36]; metabolism of nitric oxide (NO) leading to nitrosylation of parkin and nitrotyrosination of proteins [8, 61]; and function of glutathione reductase (GR), as monitored in normal, mammalian brain. P, parkin; -SH, reduced thiol group; P-S-SG, S-glutathionylation of parkin; MnSOD, Mn2+-dependent superoxide dismutase (SOD2); GPx, glutathione peroxidase; Grx, glutaredoxin

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