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Table 2 Characteristics of the investigated subgroups from the Vantaa 85 + study

From: Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study

 

No LRP in any braina or spinal cordb region (n = 164)

LRP in any braina region but no spinal cordb LRP (n = 54)

Concomitant braina and spinal cordb LRP (n = 85)

Women

138 (84%)

49 (91%)

64 (75%)

Age at death, yrs (SD)

92.3 (3.4)

92.6 (3.3)

92.4 (4.5)

Dementia

94 (57%)

39 (72%)

62 (73%)

Age at onset of dementia, yrs (SD)

87.3 (4.3)

86.5 (4.0)

87.5 (5.3)

Duration of dementia, yrs (SD)

5.1 (3.7)

6.2 (4.0)

5.0 (3.6)

APOE4

41 (27%)

24 (46%)

25 (33%)

SN neuronal loss (moderate-severe)

51 (31%)

27 (50%)

56 (66%)***

Braak NFT stage (V-VI)

45 (28%)

30 (56%)*

31 (37%)

Thal phases 4–5

106 (65%)

42 (78%)

62 (73%)

CERAD score (moderate-frequent)

100 (61%)

40 (74%)

60 (71%)

  1. LRP Lewy-related pathology, SN substantia nigra, NFT neurofibrillary tangle
  2. aLRP detected in any of the investigated brain regions: dorsal motor nucleus of Vagus (dmV) of medulla, locus coeruleus (LC) of pons, substantia nigra, amygdala, entorhinal cortex, cingulate gyrus, temporal cortex, frontal cortex, parietal cortex, anterior olfactory nucleus (AON) and peripheral olfactory bulb/peduncle (brain LRP data published previously [19, 31]). 15 cases found to have LRP only in olfactory bulb/peduncle [19] were included in the LRP in any brain region, no spinal LRP -group
  3. bLRP detected in any of the investigated spinal cord regions: dorsal horn and ventral horn at cervical 6–7, thoracic 3–4, lumbar 3–4 and sacral 1–2 levels and the intermediolateral column at thoracic 3–4 level, one case with no spinal cord regions available was excluded from the analysis
  4. The groups with either brain or concomitant brain and spinal cord LRP were individually compared with the no LRP group. Significant differences after Bonferroni correction are marked with asterisks, raw p-values are shown in Additional file 1: Table S2
  5. Demographics [30] of the study subjects have been published previously as well as clinical [27], genetic [25] and neuropathological variables (SN neuronal loss [27], Braak NFT stage and Thal phases [34], CERAD score [30])
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Acta Neuropathologica Communications

ISSN: 2051-5960

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