Fig. 3

Percent of Dentate Gyrus Neurons affected by Tau-positive Inclusions in PPA. (a–c) Box and whisker plot show percent of neurons containing an inclusion in the dentate gyrus of PiD (N = 8), CBD (N = 8), PSP (N = 8), and AD (N = 8) cases, all with a clinical diagnosis of PPA. Percent of neurons containing an inclusion in granule (a), hilar (b), and all (c) dentate gyrus neurons was found by calculating an inclusion-to-neuron ratio and converting the quotient into a percent. Patterns of significance in ratio data closely followed those of inclusion data, where PiD showed a higher percent of tau-positive granule and hilar cells than all other groups. CBD showed a slight predilection for granule cell tau-positivity, and AD had a clear preference for tau-positivity in hilar regions. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Note the large difference in the relative scale of the y-axis across all bar graphs. Whiskers indicate minimum and maximum densities, and the box delineates lower and upper quartiles. Each dot represents an individual case. Line within the box represents median