Fig. 11

AD-like degus exhibit similar distribution patterns of tau pathology and microglia activation as those seen in the 3xTg mouse model and human AD. (a-c) Confocal immunofluorescence micrographs show microglial cells labeled by IBA-1 (red, arrows) and neurofibrillary-tangle-like structures stained with PHF-1 antibody (green, arrows) in the specific regions including hippocampal CA1, MFC (medial frontal cortex), entorhinal cortex (EC), retrosplenial cortex (RSC), and white matter tracts (WMT), areas in the AD-like degu brain (a), and those in hippocampal CA1 in 3xTg-AD mouse (b), and in medial prefrontal cortex (MFC) from a postmortem human AD brain (c). Cell nuclei are counterstained with DAPI as blue