Fig. 2

Behavioral effects of αSyn reduction in male NTG and APP mice. Male APP and NTG controls were tested in the Barnes circular maze (BCM) at six months of age. A, B Spatial learning of the BCM task was reflected by reductions in escape latency (A) and distance traveled (B). C, D Measurements of freezing episode numbers (C) and average animal speed (D) in the BCM task were used to assess phenotypic changes other than spatial learning. E Quantitative assessment of animal trajectories during the learning phase using path efficiency. F, G Spatial memory retention in the BCM task was determined by target quadrant occupancy (F) and by assessment of path traces (G). Data represent mean ± SEM; ★P < 0.05 compared to NTG + PBS, ☆P < 0.05 compared to mice of the same genotype in the other treatment group, n = 8 mice/treatment/genotype