Table 2 Summary of the bioassays performed in mice to compare the ShTgSPON inoculum with atypical scrapie and SSPB/1. Mean dpi of positive animals ± SEM (positive/inoculated). NP: Not performed
From: Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model
| Â | Tg338 (ovine VRQ PrPC) | Tg501 (ovine ARQ PrPC) | TgVole 1x | TgVole 4x | Bank vole | |
|---|---|---|---|---|---|---|
| Â | 1st passage | 2nd passage | 1st passage | 1st passage | 1st passage | 1st passage |
ShTgSPON | 172 ± 5 (11/11) | 177 ± 8 (10/10) | 455 ± 14 (12/12) | 120 ± 1 (13/13) | 59 ± 2 (5/5) | 256 ± 14 (12/12) |
SSBP/1 | 72 ± 1 (11/11) | ND | 502 ± 27 (5/5) | ND | ND | 523 ± 62 (9/10) |
Atypical scrapie | 239 ± 2 (12/12) | 144 ± 3 [41]b | 577 ± 7 (5/5)a | 135 ± 6 (17/17) | 80 ± 2 (4/4) | 247 ± 24 (9/9)c |