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Table 1 Summary of the bioassays performed in TgShI112 mice. Mean dpi of positive animals ± SEM (positive/inoculated). NP: Not performed

From: Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model

 

TgShI112 L460

TgShI112 L456

 

1st passage

1st passage

ShTgSPON

162 ± 12 (8/8)

152 ± 11 (9/9)

SSBP/1

 > 570 (0/10)a

572 (1/5)b

Atypical Scrapie

ND

177 ± 14 (14/14)

Sheep BSE

590 ± 20 (6/6c)

ND

  1. aOne animal was euthanized at 380 dpi with spontaneous atypical profile. Endpoint established at 579 dpi
  2. bIn one animal a fine punctate PrPres signalling was observed in the medulla oblongata, absence of atypical profile. IDEXX Positive
  3. cA seventh animal was prematurely euthanized at 352 dpi and was negative, it was excluded from the calculations. ND: not determined