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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson’s-like pathology burden

Fig. 5

Quantification of pTau positive pathology in the SNpc. Representative images of 4× and 8× r-mTBI pTau pathology localized to TH+ dopaminergic neurons (A1–A9). Counts of pTau inclusions in TH+ neurons in shams and 4× r-mTBI rat SNpc (B). Counts of pTau inclusions in TH+ neurons in shams and 8× r-mTBI rat SNpc (C). Representative images of objects counted in monomer or PFF injected groups with and without 8× rmTBIs, ipsilateral to the injection (D1–D9). Counts of pTau inclusions in TH+ neurons in the SNpc ipsilateral to the injection of PFFs or monomers with and without 8× r-mTBI (E). Representative images of objects counted in monomer or PFF injected groups with and without 8× r-mTBIs, contralateral to the injection (F1–F9). Counts of pTau inclusions in TH+ neurons in the SNpc contralateral to the injection of PFFs or monomers with and without 8× r-mTBI (G). White arrowheads indicate pTau aggregate pathology localized to TH+ dopaminergic neuron that was counted

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Acta Neuropathologica Communications

ISSN: 2051-5960

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