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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson’s-like pathology burden

Fig. 3

Rare false inclusions that meet 2 of the three criteria for authentic Lewy Body-like inclusions are present in or near dopaminergic neurons. 8× r-mTBI side contralateral to monomer or PFF injection stained positive for aggregated pSyn but the inclusions were partially or entirely extracellular. Side contralateral to PFF injection without 8× r-mTBI also displayed rare false inclusions (A1C4). Authentic Lewy body-like inclusions have a perinuclear spiral contained within the TH+ cell and are near other cells with either authentic Lewy body-like inclusions or Lewy neurites (D1D4). White arrowheads indicate TH+ neuron of interest with pSyn channel off (A2, B2, C2, and D2). Arrowheads indicate false inclusions (A3A4, B3B4, C3C4) and authentic inclusions in (D3D4)

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