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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis

Fig. 4

Microglia have distinct expression signatures based on spatial context in Rasmussen encephalitis. a Example ROIs representing a microglial nodule (left, yellow) versus unaggregated microglia (right, light blue) with immunofluorescent staining of microglia (IBA1, green), lymphocytes (CD45, red), and nuclei (SYTO13, blue). b Volcano plot of significant abundantly expressed proteins detected in microglial nodules versus unaggregated microglia. c 20 × micropictograph confirming high expression of CD8 in CD45+ cells near microglial nodules. d-g Relative cell type marker expression d T-cell subtype marker expression e macrophage subtype marker expression f cell activation markers g in CD45+ ROIs for each patient

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