Fig. 3
From: Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain
Overview of the number of differentially methylated promoter-associated protein-coding regions for dentate gyrus and cingulate gyrus by cell type. Barplots display the number of significant (FDR p-value < 0.05) differentially methylated promoter regions of protein-coding genes. Each barplot shows the results for one brain region and neuropathological score combination. Color coding of the bars reflects the different cell types. The dentate gyrus (DG) and cingulate gyrus (CG) were the two regions with the highest amount of differentially methylated promoters (DM promoters, DMPTs) across neuropathological scores. We did not discover any DM promoters across different NIA-AA C scores, and there were no differentially methylated sites found in bulk data. FDR False discovery rate, Olig Oligodendrocytes, OPCs Oligodendrocyte Precursor Cells, CG Cingulate Gyrus, DG Dentate Gyrus, NIA-AA National institute of Aging Alzheimer's Association, AD Alzheimer’s Disease