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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders

Fig. 5

Astrocytic aSyn accumulations occur in several limbic regions of LB disease brains. a The astrocytic aSyn accumulations were encountered in the EC (SNCA G51D3), amygdala (DLB1), hippocampal CA4 (SNCA duplication) and insula (PDD5) regions of LB disorders. b The astrocytic accumulations showed morphological diversity, with the majority showing a star shape and labelling the ramified processes (cingulate cortex layers V–VI). c Some of the astrocytic aSyn appeared as cytoplasmic accumulations (hippocampal CA4). Figure 5b, c images from a SNCA duplication brain stained with the LASH-BL 34–45 antibody. aSyn = alpha-synuclein; CA4 = cornu ammonis 4; DLB = dementia with Lewy bodies; EC = entorhinal cortex; LB = Lewy body; PD = Parkinson’s disease; PDD = Parkinson’s disease with dementia

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Acta Neuropathologica Communications

ISSN: 2051-5960

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