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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology

Fig. 2

Use of average copy number of genes sequenced by the Oncomine panel located on chromosomes 1p, 1q, 19p, 19q in order to detect 1p/19q co-deletion. A Average copy number for genes sequenced on chromosomes 1p, 1q, 19p, and 19q for IDH-mutant infiltrating astrocytoma (IA_IDH_MUTANT), IDH- wild type infiltrating astrocytoma in adults (IA_IDH_WT), and oligodendroglioma (OLIGO). B Map of chromosomes 1 and 19 showing distribution of genes sequenced by the Oncomine panel. C Average copy number for genes on 1p/19q (left panel) and 1q/19p (right panel) for each subgroup of infiltrating glioma where the red line represents suggested cut-off value of 1.65 for average copy number of genes sequenced on 1p and 19q to detected co-deletion. D ROC curve for determination of cut-off value with highest sensitivity (100%) and specificity (98%)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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