Fig. 2

Kaplan Meier survival curve showing increased mortality in PAI-2-deficient (Serpinb2^−/−) mice (a). Macroscopical images of PAI-2-deficient mouse brains (b-e). Basal view of the brain cut through the mesencephalon showing subarachnoidal bleeding (b). Left frontal view of the brain showing subdural hematoma over the left hemisphere (c). Basal view of the brain showing subarachnoidal and intracerebral hematoma (asterisk) (d). Multiple small cortical hemorrhages (e). Number of hemorrhages (f) and total bleeding areas (g) 48 h after pneumococcal inoculation in wt and PAI-2-deficient mice. The scale bar indicates 1 mm in length