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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells

Fig. 2

Schematic representation of key findings from studies on hiPSC-derived neurons. Neuronal defects found in hiPSC-based models of SZ can be characterized as reduced neuronal connectivity and neurite outgrowth, synaptic and mitochondrial dysfunction as well as neurodevelopmental and miRNA impairments. Additionally, changes in electrophysiology can be characterized as reduced neuronal firing, excitability, depolarization and overall neuronal activity

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