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Table 2 Cox proportional hazards ratio hazard ratio (HR) and P-value for each variable. N = 86, unless otherwise indicated

From: Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation

Characteristic

HR PFS

P PFS

HR OS

P OS

Univariate

Age (continuous variable)

–

0.2

1.03 (1.01–1.06)

0.02

Age (Categorical variable: > or < 62)

 

0.4

1.8 (1.1–3.1)

0.03

MGMT promoter methylation status (n = 72)*

0.5 (0.28–0.9)

0.02

0.47 (0.26–0.88)

0.02

Gender

–

0.8

0.56 (0.3–0.97)

0.04

Resection

–

0.08

–

0.7

CD133

–

0.6

–

0.8

SOX2

–

1.0

–

0.9

NES Percentage

–

0.8

–

0.4

NES blood vessels

–

0.6

–

0.5

Multivariate

Gender

1.2

0.7

0.6 (0.3–1.1)

0.1

Age (Categorical variable: > or < 62)

0.4

1.4

1.9 (1.0–3.6)

0.05

MGMT Promoter Methylation (n = 72)*

0.02

0.4 (0.2–0.9)

0.5 (0.4–1.3)

0.04

  1. Significant results with p</=0.05 were intended to be bold and italicized
  2. * MGMT status unknown in 14 cases, and these cases are not included.
  3. HR Hazard Ratio, P p-value, PFS Progressive free survival, OS Overall survival  p values at 0.05 or below are italicized and bold