Fig. 5

NFT position as a geometric network and subsequent graph metrics. a A representation of NFT position as a geometric network. Each NFT is represented as a node in a unidirectional binary graph, where an edge exists between two nodes if the Euclidean distance between them is less than some value r. In this figure r = 250 μm. b Group comparison of non-cognitively impaired (NCI) vs cognitively impaired (CI) mean clustering coefficient. Asterisk denotes p < 0.05. Two-sample t-test between groups yielded a t-statistic of  − 2.97 and p = 0.0031. c: Example of hippocampal whole slide image with high mean clustering coefficient (0.75). d Example of hippocampal whole slide image with low mean clustering coefficient (0.47)