Table 1 Summary demographic data of donors. Post-mortem interval, age at death and ECAS score are presented as mean ± S.D. ECAS score was significantly lower in ALSci compared to ALSnoci (*2-tailed t-test; p = 0.0005). No differences were found between any other group comparisons. Presence of pTDP43 pathology was assessed blind to diagnosis and cases were classed as pTDP43 positive if aggregates were observed anywhere in the paraffin-embedded section
Experimental group | n | Post-mortem interval (hrs) | Age at death (years) | ECAS score (Max. 136) | Gender (% Male) | pTDP43 BA4 (positive cases) | pTDP43 BA9 (positive cases) |
|---|---|---|---|---|---|---|---|
Control | 11 | 74 ± 24 | 66 ± 18 |  | 64 | 0/11 | 1/11 |
ALS | 18 | 81 ± 29 | 64 ± 10 |  | 56 | 15/18 | 10/18 |
ALSnoci | 9 | 95 ± 29 | 66 ± 9 | 117 ± 5 | 44 | 8/9 | 5/9 |
ALSci | 9 | 67 ± 24 | 62 ± 11 | 99 ± 11* | 67 | 7/9 | 6/9 |
ALS c9 −ve | 12 | 88 ± 29 | 58 ± 9 | 108 ± 15 | 58 | 10/12 | 6/12 |
ALS c9 +ve | 6 | 66 ± 27 | 67 ± 9 | 108 ± 8 | 50 | 5/6 | 4/6 |