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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex

Fig. 5

Impact of C9ORF72-RE on ALS synaptic proteome. A Heatmap showing the protein expression differences between C9ORF72-ve and C9ORF72-RE +ve groups. B KEGG pathways revealing the most enriched signalling pathways in both groups. Diagram was plotted based on fold enrichment and gene counts/pathway (dot size), coloured based on -log10(FDR). C Top 10 up- and downregulated proteins per group. D Heatmap shows C9ORF72 +ve-specific protein changes with the number of altered proteins highlighted. E Gene ontology analyses show the top enriched molecular terms using C9ORF72 +ve-specific protein IDs. F Schematic figure shows the subsynaptic localization of the C9ORF72 +ve-specific proteins discovered by the SynGO database. Panel was created using BioRender.com

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