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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex

Fig. 4

Cognitive impairment is associated with specific pathway changes in BA4. A Heatmap shows the protein expression differences between non cognitively impaired (ALSnoci) and impaired (ALSci) groups. B Further enrichment analysis shows the most enriched KEGG pathways which were plotted based on fold enrichment and gene counts/pathway (dot size), coloured based on -log10(FDR). C Top 10 up- and downregulated proteins per highlighted group. D Heatmap shows the ALSci-specific protein changes with the number of proteins noted. E Gene ontology analysis shows the top enriched molecular terms based on the ALSci-specific proteins. F Schematic figure shows the localization of the ALSci-specific proteins, discovered by the SynGO database. Panel was created using BioRender.com

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Acta Neuropathologica Communications

ISSN: 2051-5960

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