Table 1 Sample information
From: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Sample ID | Tissue, location | Age, Gender PMT | NUCLEI RNA-SEQ | SC RNA-SEQ | Pathological diagnosis |
|---|---|---|---|---|---|
Cell-type specific FANS Validation, TL vs. TLE | |||||
10662 | TL control, temporal lobe neocortex | 34yo, M 12 h PMT | ✓ | No neuropathological changes seen in cortex | |
10355 | TL control, temporal lobe neocortex | 45yo, F 12 h PMT | ✓ | No neuropathological changes seen in cortex | |
10997 | TL control, temporal lobe neocortex | 27yo, M 21 h PMT | ✓ | No neuropathological changes seen in cortex | |
12321 | TLE, temporal lobe neocortex | 50yo, M | ✓ | Cortical and Chaslin Gliosis; White matter neuronal heterotopia | |
10308 | TLE, temporal lobe neocortex | 29yo, F | ✓ | Cortical and Chaslin gliosis; FCD Ia | |
12726 | TLE, temporal lobe neocortex | 13yo, M | ✓ | Cortex without pathologic changes; * | |
14431 | TLE, temporal lobe neocortex | 28yo, M | ✓ (10X, v2) | Cortical Gliosis; Ectopic white matter neurons with mild hypertrophy; | |
19619 | TLE, temporal lobe neocortex | 31yo, F | ✓ (10X, v2) | Chaslin gliosis; * | |
20188 | TLE, temporal lobe neocortex | 58yo, F | ✓ (10X, v3) | Cortical and Chaslin gliosis, rare neurons with hypertrophy and disoriented dendrites; * | |
12814 | TLE, temporal lobe neocortex | 11yo, M | (10X, v1) | Chaslin gliosis; * | |
13059 | TLE, temporal lobe neocortex | 8yo, M | ✓ (10X, v1) | Gliosis, neuronal heterotopia; | |
Sample ID | Tissue, location | Age, Gender | Ki-67 IF | In vitro assays | Pathological diagnosis |
|---|---|---|---|---|---|
Phenotypic analysis of epilepsy glia | |||||
12321 | TLE, temporal lobe neocortex | 50yo, M | ✓’ (high) | ✓ | Cortical and Chaslin Gliosis; White matter neuronal heterotopia; |
10308 | TLE, temporal lobe neocortex | 29yo, F | ✓ (low) | ✓ | Cortical and Chaslin gliosis; FCD Ia; |
12726 | TLE, temporal lobe neocortex | 13yo, M | ✓’ (high) | Cortex without pathologic changes; * | |
14431 | TLE, temporal lobe neocortex | 28yo, M | ✓(low) | ✓ | Cortical Gliosis; Ectopic white matter neurons with mild hypertrophy; |
12319 | Epilepsy, frontal lobe neocortex | 27yo, M | ✓’ (high) | Chaslin Gliosis; Ischemic changes | |
12433 | Epilepsy, TS, frontal lobe neocortex | 4yo, M | ✓ (low) | ✓ | Cortical and Chaslin Gliosis; ** |